Alzheimer’s Disease and Dementia Resource

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Natural Supplements Help Alzheimer’s

Degenerative neurological diseases such as Alzheimer’s and Parkinson have a severe social and economic impact and it is only quite recently that they have been recognised and accorded great attention by mainstream medicine.  This is greatly due to the fact that age is the greatest risk-factor for such conditions and people are simply living longer and becoming susceptible to it.

Unfortunately, modern medicine cannot cure Alzheimer’s or Parkinson’s and many sufferers and families undergo an extremely traumatic experience as loved ones are slowly lost to these awful conditions.  However, there is mounting scientific and anecdotal evidence that nutritional supplements can play a key role in the prevention and improvement of these neurological conditions and greatly aid general cognitive improvement.

What happens in the brain affected by Alzheimer’s or Parkinson’s?

In the normal brain, signals in the form of electrical impulses traverse along nerves from our body to parts of the brain.  The nerve signals bridge gaps (synapse) between the nerve cells (neurons), aided by chemicals known as ‘neurotransmitters’.  Each nerve cell communicates with many others forming networks and the signals communicated are essential not only for brain activities such as memory and language but also for controlling movement.

The diseases are characterised by a gradual reduction in the number of nerve cells, a shrinking of the brain, and cognitive functions progressively worsen as more cells are destroyed.  There is also a reduction in the amount of the neurotransmitters, acetylcholine and dopamine, attributing to poor cellular communication.

Inside the nerve cells, ‘tangles’ form, which is a build up of the protein ‘tau’, disrupting the signals cells pass to one another and ultimately ending in the death of the cell.

Another characteristic of the both Alzheimer’s and Parkinson’s disease development are ‘plaques’ which accumulate between the cells, again disrupting signals, caused by another protein, ‘beta-amyloid’.  This promotes inflammation and oxidation.

Plaques and tangles form in a predictable pattern, blocking communication amongst nerve cells and disrupting the activities that the cell needs to survive.

Four Plant Extracts Proven to Improve Alzheimer’s

Phospahtidylserine (PS)

Phosphatidylserine is necessary in the brain for effective neurotransmission as it is important for the production of acetycholine, the aforementioned neurotransmitter which sufferers of Alzheimer’s and Parkinson’s have a deficiency of.  It has been proven to improve behaviour, mental function and mood, as was found in a study of 494 elderly individuals who suffered from moderate to severe mental decline, who took 300mg per day for six months. (1)

The FDA allows the claim: “Consumption of phosphatidylserine (PS) may reduce the risk of cognitive dysfunction in the elderly.”

Phosphatidylcholine (PC)

Phosphatidylcholine has a key role in the maintenance of the cell-membrane integrity.  Strengthening the cell walls is vital as the diseased cells effectively leak choline, and so reduce the production of the neurotransmitter, acetycholine.

PS it is vital to all of the basic biological processes, including the forming of cellular energy and communication within, and between the cells, and plays a crucial role in many of the brains’ processes. (2) 

Oleic Acid (Omega 9 Fatty Acid)

Myelin, the protective sheath that covers the brain cells necessary for communication, is composed of 30% protein and 70% fat. One of the most common fatty acids in myelin is oleic acid, which is crucial for brain development and function as it helps to manufacture and maintain cell membranes.  Scientists have reported that neurodegenerative disorders such as Parkinson’s and Alzheimer’s appear to exhibit membrane loss of fatty acids and that oleic acid may help to delay their onset or reduce the damage to the brains’ functions which these diseases elicit. (3) 

The reduction of oleic acid correlates to a decline in the structural and functional integrity of the cells.

Quercetin

Quercetin is a flavanoid which has strong antioxidant properties.  The build up of plaques indicative in Alzheimer’s and Parkinson’s which kills brain cells is related to oxidative stress and neurotoxicity.

Clinical research suggests that quercetin showed protective effects against toxicity by modulating oxidative stress and that it may provide a promising approach for the treatment of AD and other oxidative-stress-related neurodegenerative diseases. (4)

Summary

There are dozens or safe, plant extracts which have beneficial properties for nerve cell health and a combination of them can provide broad-spectrum protection against the multiple mechanisms involved in neurological deterioration.  In addition, plant extracts can play an important role in the research of new pharmacological solutions.

(1) Cenacchi T, Bertoldin T, Farina C, et al. Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration. Aging(Milano). 1993;5:123-133.

2. Canty, DJ and Zeisel, SH. Nutr Reviews. 52;327-339, 1994

3. International Journal of Developmental Neuroscience, July 2000

4. Protective effect of quercetin in primary neurons against Aβ(1–42): relevance to Alzheimer’s disease. The Journal of Nutritional Biochemistry, Volume 20, Issue 4, April 2009, Pages 269-275

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Stages of Alzheimer’s Disease

Jul-25-2009 By admin

There are three primary stages of Alzheimer’s disease, including a mild, moderate and severe stage. Find out how memory loss increases throughout the stages of Alzheimer’s disease with helpful information in this free video on Alzheimer’s disease.

Duration : 0:1:46

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Alzheimer’s Disease

Jul-25-2009 By admin

Alzheimer’s Disease is the #1 type of dementia in the elderly — about 60-80% of cases. About 4 million Americans. Occurs between ages 40-90, is progressive, and causes memory loss, global cognitive dysfunction, personality changes, and loss of independence due to poor executive functioning. It comes on slowly, usually starting with short-term memory loss.
It is hard on the 3 million family members/friends taking care of those with Alzheimer’s Disease, costing about $47,000 a year, including the personality changes that can range from having no personality to being hostile.
We don’t know what causes Alzheimer’s Disease and we don’t have a cure, though medicines help delay the progressive symptoms. Only on autopsy are the classic brain findings seen: amyloid-beta protein deposits and intracellular neurofibrillary tangles. These 2 findings are thought to be results on an underlying pathologic process that destroys the brain cells.

Duration : 0:2:24

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Immune therapy Alzheimer’s hope

Jul-23-2009 By admin

Immune therapy Alzheimer’s hope

Intravenous injection

Antibody therapy is used to treat cancer

An immune system therapy given to cancer patients could have the added benefit of reducing the risk of Alzheimer’s disease, a study suggests.

A US team found patients who had received antibody treatment had more than 40% less risk of Alzheimer’s than people who had not.

Writing in Neurology, they said a bigger study was needed to confirm their findings.

UK experts said immunotherapy was an important area of research.

So far, scientists have been looking at it as a way of treating people who already have Alzheimer’s.

The idea is that immune based therapies affect the formation of beta-amyloid plaques in the brain, which are characteristic of Alzheimer’s, possibly by suppressing the inflammatory response in the brain.

People with the disease have lower levels of anti beta-amyloid antibodies, so experts are looking at ways of boosting levels - including immunisation.

But this study investigated whether or not people who had been given the treatment already, for another condition, had some protection.

‘Treat the cause’

The team from Mount Sinai School of Medicine in New York looked at the records of 847 people who had been given at least one intravenous immunoglobulin

(IVIg) treatment for cancers, such as leukaemia, or immune system disorders.

All were over 65 and had received the treatment between April 2001 and August 2004.

Their records were then compared with those of 847,000 people who had not needed the therapy who were similar Alzheimer’s risk factors to the treated group.

The records were held by a medical insurance company, and so detailed the illnesses and treatments people had claimed payments for.

Patients were followed up to August 2007. It was found that only 2.8% of those treated with IVIg developed Alzheimer’s, compared with 4.8% of those not treated.

Dr Howard Fillit, who led the study, said: “IVIg has been used safely for more than 20 years to treat other diseases but is thought to have an indirect effect on Alzheimer’s disease by targeting beta-amyloid, or plaques in the brain.

“Our study provides evidence that previous IVIg treatments may protect against Alzheimer’s disease.

“The current Alzheimer’s drugs on the market treat the symptoms of the disease. Immunization could treat the underlying cause.”

But he added: “These findings do not constitute an endorsement of IVIg treatment for Alzheimer’s disease. A large scale clinical trial is underway to determine whether IVIg could be an effective treatment for Alzheimer’s.”

Neil Hunt, chief executive of the Alzheimer’s Society, said: “This is a really encouraging epidemiological study.

“Clinical trials are now underway in this area and we look forward to the results.”

But he added: “Introducing large amounts of antibodies could cause serious side effects so important questions will need to be answered before this treatment becomes available.”

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Provided by the Alzheimers ociation, Greater New Jersey Chapter. www.alznj.org. www.arcmesa.org. The information contained on this video should not be considered medical guidance or professional advice. The Alzheimer’s ociation, its affiliates or agents, or any other parties involved in the preparation or publication of this video are not responsible for errors or omissions in information provided on this video or any actions resulting from the use of such information. Viewers are encouraged to confirm the information contained herein with other reliable sources and to direct any questions concerning their personal health to licensed physicians or other appropriate health care professionals.

Visit us at www.alznj.org or call the 24/7 Helpline at 1.800.883.1180.

Duration : 0:10:42

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There is substantial evidence that an active mind helps increase the survival of neurons in the brain that are at risk of Alzheimer’s Disease. Chemicals in the brain called trophic factors, released during activity, may be at the heart of this saving effect.

Duration : 0:5:13

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After one year of successful treatment with sustained improvement, daughter discusses the value of perispinal etanercept for her mother and her family.

Duration : 0:2:39

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Can using pictures aid memory recall in people with Alzheimer’s disease?
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Inspired by Maria Shriver’s book, “What’s Happening to Grandpa?”, this film tells five stories of children, ages 6-15, who are coping with grandfathers or grandmothers suffering from Alzheimer’s disease. Maria Shriver provides commentary and delivers valuable “lessons” for the kids, urging them not to blame themselves for what their grandparents do or say. For more about The Alzheimer’s Project, log on to http://www.hbo.com/alzheimers

Duration : 0:30:49

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Could how fast you button your shirt be an early indicator of Alzheimer’s disease?
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